LRP12 and MYOT

Data Source:
HPRD (in vivo, two hybrid)

		LRP12	MYOT
Description		LDL receptor related protein 12	myotilin
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Clathrin-coated Pit Integral Component Of Membrane	Plasma Membrane Actin Cytoskeleton Z Disc Axon Sarcolemma Neuronal Cell Body
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Protein Binding	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding
	Biological Process	Neuron Migration Endocytosis Signal Transduction Neuron Projection Development Regulation Of Growth	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization
Pathways		Retinoid metabolism and transport
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD)
GWAS		Blood protein levels ( 30072576) Glaucoma (primary open-angle) ( 22570617) HOMA-B (corrected for HOMA-IR) ( 30369944) Impulsivity (attentional) ( 30718321) Irritable mood ( 29500382) Periodontitis (DPAL) ( 24024966) Systolic blood pressure ( 28739976) Vascular endothelial growth factor levels ( 21757650)	Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		6 interacting genes: ACTN2 MYOT NMRK2 RACK1 SNAPIN ZFYVE9	17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63
Entrez ID		29967	9499
HPRD ID		17447	04981
Ensembl ID		ENSG00000147650	ENSG00000120729
Uniprot IDs		Q59H02 Q9Y561	A0A0C4DFM5 B4DT68 Q9UBF9
PDB IDs			2KDG 2KKQ
Enriched GO Terms of Interacting Partners?
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