DPH3 and RPL8

Data Source:
BioGRID (two hybrid)

		DPH3	RPL8
Description		diphthamide biosynthesis 3	ribosomal protein L8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytosol Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Polysomal Ribosome Postsynapse
	Molecular Function	Protein Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5.8S RRNA Binding
	Biological Process	TRNA Wobble Uridine Modification Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Negative Regulation Of Protein Secretion Positive Regulation Of Binding	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Cellular Response To Nerve Growth Factor Stimulus
Pathways		Synthesis of diphthamide-EEF2	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS			Blood metabolite levels ( 26401656) Logical memory (immediate recall) in normal cognition ( 29274321)
Interacting Genes		6 interacting genes: ADIPOR1 MEOX2 PIH1D2 RPL8 SERGEF ZNF438	14 interacting genes: ARIH2 ARL15 C11orf49 CHDH DPH3 DUSP23 DUX4 FGFR3 IL7R MINDY3 NUDT3 ST3GAL3 UBE2I UPF2
Entrez ID		285381	6132
HPRD ID		16412	16044
Ensembl ID		ENSG00000154813	ENSG00000161016
Uniprot IDs		Q96FX2	P62917
PDB IDs		2JR7	4CCM 4CCN 4CCO 4UG0 4V6X 4Y3O 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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