GLO1 and MAP3K13

Data Source:
BioGRID (two hybrid)

		GLO1	MAP3K13
Description		glyoxalase I	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Cytoplasm Membrane
	Molecular Function	Lactoylglutathione Lyase Activity Protein Binding Zinc Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding
	Biological Process	Carbohydrate Metabolic Process Pyruvate Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Pyruvate metabolism
Drugs		Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione Mercaptoethanol S-benzylglutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate	Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 29317602) Restless legs syndrome ( 29029846)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822)
Interacting Genes		4 interacting genes: IKBKG MAP3K13 MEOX2 PJA1	8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		2739	9175
HPRD ID		00730	05372
Ensembl ID		ENSG00000124767	ENSG00000073803
Uniprot IDs		Q04760 X5DNM4	O43283
PDB IDs		1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U
Enriched GO Terms of Interacting Partners?
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