DESI1 and ZBTB46

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		DESI1	ZBTB46
Description		desumoylating isopeptidase 1	zinc finger and BTB domain containing 46
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Protein-containing Complex	Chromatin Nucleus
	Molecular Function	Protein Binding Identical Protein Binding Importin-alpha Family Protein Binding SUMO-specific Isopeptidase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Removal	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Differentiation
Pathways
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Birth weight ( 31043758) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421) Marginal zone lymphoma or multiple sclerosis ( 31407831) Mean corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Processed meat consumption ( 32066663) Prostate cancer ( 23535732) Trunk fat mass adjusted for trunk lean mass ( 32239398) Type 2 diabetes (adjusted for BMI) ( 30297969) Ulcerative colitis ( 28067908 21297633) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		33 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RNF4 RPS27A SHISA4 SHISA5 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLN2 UBQLNL UHRF2 XPO1 ZBTB46	1 interacting genes: DESI1
Entrez ID		27351	140685
HPRD ID		18590	16567
Ensembl ID		ENSG00000100418	ENSG00000130584
Uniprot IDs		Q6ICB0	A0A494BZW5 Q6ZMU8 Q86UZ6
PDB IDs		3EBQ
Enriched GO Terms of Interacting Partners?
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