GLA and GPR17

Data Source:
HPRD (in vitro)

		GLA	GPR17
Description		galactosidase alpha	G protein-coupled receptor 17
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Catalytic Activity Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Galactosylgalactosylglucosylceramidase Activity Protein Homodimerization Activity Raffinose Alpha-galactosidase Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Receptor Serine/threonine Kinase Binding
	Biological Process	Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Negative Regulation Of Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Oligodendrocyte Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	Leukotriene receptors G alpha (q) signalling events P2Y receptors G alpha (i) signalling events
Drugs		Migalastat
Diseases		Fabry disease
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		1 interacting genes: TERT	2 interacting genes: GNA13 GPR37
Entrez ID		2717	2840
HPRD ID		02357	04351
Ensembl ID		ENSG00000102393	ENSG00000144230
Uniprot IDs		P06280 Q53Y83	G4XH68 Q13304
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT
Enriched GO Terms of Interacting Partners?
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