MSTN and MFSD6

Data Source:
BioGRID (affinity chromatography technology)

		MSTN	MFSD6
Description		myostatin	major facilitator superfamily domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Negative Regulation Of Kinase Activity Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Pathways		FOXO-mediated transcription of cell cycle genes
Drugs		MYO-029
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31015462) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494)
Interacting Genes		6 interacting genes: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2	36 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 GJA8 GJB2 GPR152 GPR42 GPX8 LY6E MFSD4B NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2
Entrez ID		2660	54842
HPRD ID		03474	13369
Ensembl ID		ENSG00000138379	ENSG00000151690
Uniprot IDs		O14793 Q53S46	Q6ZSS7
PDB IDs		5F3B 5F3H 5NTU 5NXS 6UMX
Enriched GO Terms of Interacting Partners?
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