GBP1 and PTBP2

Data Source:
BioGRID (affinity chromatography technology)

		GBP1	PTBP2
Description		guanylate binding protein 1	polypyrimidine tract binding protein 2
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Vesicle Membrane Actin Cytoskeleton Cytoplasmic Vesicle	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body
	Molecular Function	Actin Binding GTPase Activity Protein Binding GTP Binding GDP Binding Enzyme Binding Cytokine Binding Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Hsp90 Protein Binding	RNA Binding MRNA Binding
	Biological Process	Negative Regulation Of Interleukin-2 Production Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Protein Localization To Vacuole Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Plasma Membrane	MRNA Splice Site Selection Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Remission after SSRI treatment in MDD or openness ( 29559929)	Adult body size ( 32376654) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398 30944420) Waist circumference ( 25673412)
Interacting Genes		2 interacting genes: FNTA FNTB	19 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA TOM1
Entrez ID		2633	58155
HPRD ID		02681	12233
Ensembl ID		ENSG00000117228	ENSG00000117569
Uniprot IDs		P32455	A0A6Q8PFE6 B4DSS8 B4DSU5 Q9UKA9
PDB IDs		1DG3 1F5N 2B8W 2B92 2BC9 2D4H 6K1Z 6K2D	2CQ1 2MJU 4CQ1
Enriched GO Terms of Interacting Partners?
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