NPHP4 and TMEM201

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		NPHP4	TMEM201
Description		nephrocystin 4	transmembrane protein 201
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium	Spindle Pole Integral Component Of Nuclear Inner Membrane Cytoplasm Nuclear Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Lamin Binding Actin Filament Binding
	Biological Process	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone	Fibroblast Migration Nuclear Migration Along Microtubule
Pathways		Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Senior-Loken syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)
Interacting Genes		2 interacting genes: NPHP1 RPGRIP1	23 interacting genes: CLEC17A CPLX4 CYB5R3 DNAJC1 EMD FATE1 FRMD3 GOLM2 GPR152 KCNJ9 LHFPL5 LMNA LRRC25 MFF MINAR1 NDUFAF2 PTPN5 SLC26A6 TMEM237 TMEM35A TMX2 UBC VEZT
Entrez ID		261734	199953
HPRD ID		06238	17991
Ensembl ID		ENSG00000131697	ENSG00000188807
Uniprot IDs		B3KW36 O75161	Q5SNT2
PDB IDs
Enriched GO Terms of Interacting Partners?
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