GALT and CCL19

Data Source:
BioGRID (affinity chromatography technology)

		GALT	CCL19
Description		galactose-1-phosphate uridylyltransferase	C-C motif chemokine ligand 19
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding	Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	UDP-glucose Metabolic Process Galactose Metabolic Process UDP-glucose Catabolic Process Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication G Protein-coupled Receptor Signaling Pathway Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Lymphocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Defective GALT can cause Galactosemia Galactose catabolism	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases		Galactosemia
GWAS			Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		7 interacting genes: GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 UBTD2 VAC14	8 interacting genes: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13 MEOX2 PF4V1
Entrez ID		2592	6363
HPRD ID		06106	03750
Ensembl ID		ENSG00000213930	ENSG00000172724
Uniprot IDs		A0A0S2Z3Y7 B2RAT6 P07902	Q6IBD6 Q99731
PDB IDs		1R3A 5IN3 6GQD	2MP1
Enriched GO Terms of Interacting Partners?
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