G6PC1 and NSL1

Data Source:
BioGRID (two hybrid)

		G6PC1	NSL1
Description		glucose-6-phosphatase catalytic subunit 1	NSL1 component of MIS12 kinetochore complex
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Cytosol Nuclear Speck
	Molecular Function	Glucose-6-phosphatase Activity Protein Binding Phosphotransferase Activity, Alcohol Group As Acceptor Phosphate Ion Binding	Protein Binding
	Biological Process	Glycogen Metabolic Process Glycogen Catabolic Process Gluconeogenesis Triglyceride Metabolic Process Steroid Metabolic Process Response To Carbohydrate Regulation Of Gene Expression Glucose-6-phosphate Transport Response To Food Cellular Response To Insulin Stimulus Multicellular Organism Growth Glucose Homeostasis Cholesterol Homeostasis Urate Metabolic Process Phosphorylated Carbohydrate Dephosphorylation Glucose 6-phosphate Metabolic Process Response To Resveratrol	Mitotic Sister Chromatid Segregation Cell Division
Pathways		Glycogen storage disease type Ia (G6PC) Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		4 interacting genes: CDH16 FOXO1 NSL1 SNX13	9 interacting genes: CBX1 CBX3 CBX5 DSN1 G6PC1 HSP90AA1 LRRK2 MIS12 SUGT1
Entrez ID		2538	25936
HPRD ID		01983	12378
Ensembl ID		ENSG00000131482	ENSG00000117697
Uniprot IDs		P35575	Q53FM2 Q5SY74 Q96IY1
PDB IDs			4NF9 5LSI 5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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