NEIL2 and LCN2

Data Source:
BioGRID (two hybrid)

		NEIL2	LCN2
Description		nei like DNA glycosylase 2	lipocalin 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Mitotic Spindle	Extracellular Region Extracellular Space Specific Granule Lumen Extracellular Exosome
	Molecular Function	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Enterobactin Binding
	Biological Process	Base-excision Repair Depyrimidination	Cellular Iron Ion Homeostasis Apoptotic Process Siderophore Transport Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Sequestering Of Iron Ion Positive Regulation Of Cold-induced Thermogenesis
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs		Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate	Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS		Alcohol dependence ( 23942779) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		10 interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27	61 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF C20orf85 CAMLG CCNC CDSN CHIC2 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1
Entrez ID		252969	3934
HPRD ID		16406	02551
Ensembl ID		ENSG00000154328	ENSG00000148346
Uniprot IDs		A0A024R361 Q969S2	P80188
PDB IDs		1VZP	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA
Enriched GO Terms of Interacting Partners?
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