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IL17RA and IL17A
Data Source:
HPRD
(in vivo, in vitro)
IL17RA
IL17A
Description
interleukin 17 receptor A
interleukin 17A
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
Extracellular Region
Extracellular Space
External Side Of Plasma Membrane
Molecular Function
Protein Binding
Interleukin-17 Receptor Activity
Cytokine Activity
Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
Adaptive Immune Response
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Innate Immune Response
Fibroblast Activation
Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Antimicrobial Peptide Production
Adaptive Immune Response
Apoptotic Process
Inflammatory Response
Immune Response
Cell-cell Signaling
Cell Death
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-16 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Innate Immune Response
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Defense Response To Fungus
Intestinal Epithelial Structure Maintenance
Cellular Response To Interleukin-1
Fibroblast Activation
Interleukin-17-mediated Signaling Pathway
Granulocyte Migration
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways
Interleukin-17 signaling
Interleukin-17 signaling
Interleukin-4 and Interleukin-13 signaling
Drugs
Secukinumab
Ixekizumab
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Granulocyte percentage of myeloid white cells (
27863252
)
Heschl's gyrus morphology (
25130324
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
)
Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease (
31311600
)
White blood cell count (
32888494
27863252
)
Height (
28552196
)
Interacting Genes
2 interacting genes:
IL17A
MTDH
3 interacting genes:
DPH2
IL17RA
KCNIP4
Entrez ID
23765
3605
HPRD ID
10399
04396
Ensembl ID
ENSG00000177663
ENSG00000112115
Uniprot IDs
Q96F46
Q16552
PDB IDs
3JVF
4HSA
4NUX
5N9B
5NAN
2VXS
4HR9
4HSA
4QHU
5HHV
5HHX
5HI3
5HI4
5HI5
5N7W
5N92
5NAN
5VB9
6WIO
6WIR
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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