SH3BP1 and SUN2

Data Source:
BioGRID (proximity labelling technology)

		SH3BP1	SUN2
Description		SH3 domain binding protein 1	Sad1 and UNC84 domain containing 2
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GO Annotations	Cellular Component	Exocyst Phagocytic Cup Intracellular Anatomical Structure Nucleus Cytosol Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nuclear Envelope Integral Component Of Nuclear Inner Membrane Endosome Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein-membrane Adaptor Activity Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Phagocytosis, Engulfment Actin Filament Organization Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Ruffle Assembly	Nuclear Envelope Organization Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Nuclear Matrix Anchoring At Nuclear Membrane
Pathways			Meiotic synapsis
Drugs
Diseases
GWAS			Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		14 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK POT1 RAC1 RHOA SRC SYNJ1 TERF1 TRIP10	4 interacting genes: HGS NRM RAB5B RPS20
Entrez ID		23616	25777
HPRD ID		10227	15611
Ensembl ID		ENSG00000100092	ENSG00000100242
Uniprot IDs		A0A2X0SFX7 Q9Y3L3	A0A024R1P7 B4E2A6 Q9UH99
PDB IDs		4J9D 4J9F	3UNP 4DXR 4DXS 4DXT 4FI9
Enriched GO Terms of Interacting Partners?
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