POFUT1 and ID1

Data Source:
HPRD (in vivo)

		POFUT1	ID1
Description		protein O-fucosyltransferase 1	inhibitor of DNA binding 1, HLH protein
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Golgi Apparatus Centrosome
	Molecular Function	Fucosyltransferase Activity Peptide-O-fucosyltransferase Activity	Protein Binding Protein C-terminus Binding Transcription Factor Binding Identical Protein Binding Protein Dimerization Activity Protein N-terminus Binding Proteasome Binding Transcription Regulator Activity Transcription Regulator Inhibitor Activity
	Biological Process	Angiogenesis Somitogenesis Fucose Metabolic Process Regulation Of Transcription, DNA-templated Protein O-linked Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway O-glycan Processing Protein O-linked Fucosylation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Transcription By Transcription Factor Localization Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Negative Regulation Of Protein Binding Positive Regulation Of Actin Filament Bundle Assembly Circadian Regulation Of Gene Expression Cell-abiotic Substrate Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Dendrite Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Regulation Of Vasculature Development Cellular Response To Peptide Cellular Response To Dopamine Cellular Response To Nerve Growth Factor Stimulus
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum	Oncogene Induced Senescence NGF-stimulated transcription
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)	Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		4 interacting genes: AKT2 DLL1 JAG1 NOTCH1	24 interacting genes: APPL1 ASCL3 CASK COPB1 DNMT3L ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MSGN1 MYF5 MYF6 MYOD1 MYOG PSMD4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4 TRIM55 TRIM63
Entrez ID		23509	3397
HPRD ID		06319	08980
Ensembl ID		ENSG00000101346	ENSG00000125968
Uniprot IDs		Q9H488	P41134
PDB IDs		5UX6 5UXH
Enriched GO Terms of Interacting Partners?
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