SEC11A and KLHL25

Data Source:
BioGRID (proximity labelling technology)

		SEC11A	KLHL25
Description		SEC11 homolog A, signal peptidase complex subunit	kelch like family member 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Signal Peptide Processing	Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) ( 24025145) Aging traits ( 17903295) Birth weight ( 31043758) Idiopathic pulmonary fibrosis ( 29066090) Offspring birth weight ( 31043758) Psychosis (methamphetamine induced) ( 23594818) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6	1 interacting genes: ACLY
Entrez ID		23478	64410
HPRD ID		07503	07780
Ensembl ID		ENSG00000140612	ENSG00000183655
Uniprot IDs		A0A024RC78 H0YKT4 P67812	Q9H0H3
PDB IDs
Enriched GO Terms of Interacting Partners?
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