SEC11A and AGBL1

Data Source:
BioGRID (affinity chromatography technology)

		SEC11A	AGBL1
Description		SEC11 homolog A, signal peptidase complex subunit	AGBL carboxypeptidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Metallocarboxypeptidase Activity Zinc Ion Binding Tubulin Binding
	Biological Process	Signal Peptide Processing	Proteolysis C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Activated partial thromboplastin time ( 22703881) Bitter alcoholic beverage consumption ( 31046077) Coronary artery calcification ( 23870195) Cytomegalovirus antibody response ( 21993531) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Ischemic stroke ( 26089329) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Migraine ( 21448238) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Neurociticism ( 29500382) Neuroticism ( 29255261) Psychosis (methamphetamine induced) ( 23594818) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rostral middle frontal gyrus volume ( 31530798) Schizophrenia ( 18347602) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triiodothyronine levels ( 30843173)
Interacting Genes		5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		23478	123624
HPRD ID		07503	07115
Ensembl ID		ENSG00000140612	ENSG00000273540
Uniprot IDs		A0A024RC78 H0YKT4 P67812	Q96MI9
PDB IDs
Enriched GO Terms of Interacting Partners?
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