CRTC1 and MAP3K1

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CRTC1	MAP3K1
Description		CREB regulated transcription coactivator 1	mitogen-activated protein kinase kinase kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Nuclear Body Dendrite Neuronal Cell Body Glutamatergic Synapse	Cytosol
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding
	Biological Process	Memory Viral Process Positive Regulation Of CREB Transcription Factor Activity Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Homotetramerization Energy Homeostasis Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Dendrite Development Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Membrane Hyperpolarization	MAPK Cascade Activation Of MAPKK Activity MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock Circadian Clock	MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs			AZD-8330 Binimetinib Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Body fat percentage ( 26833246) Body mass index ( 28552196 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Estimated glomerular filtration rate ( 31152163) Gastroesophageal reflux disease ( 31527586) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Menarche (age at onset) ( 21102462 25231870)	Alanine transaminase levels ( 29403010) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030) Breast cancer (early onset) ( 24493630) Brown vs. black hair color ( 30531825) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 25631608) Fasting glucose in pregnancy (gestational week 14-16) ( 30324795) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Initial pursuit acceleration ( 29064472) Lung function (FEV1) ( 30061609) Refractive error ( 32231278) Sexual dimorphism in anthropometric traits ( 23754948) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 28334899) Triglycerides ( 24097068 20686565) Type 2 diabetes ( 23209189) Urate levels (BMI interaction) ( 25811787) Waist circumference ( 23966867) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		4 interacting genes: CREB1 MAP3K1 SRPK2 YWHAG	95 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1 TOM1L2 TP53 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 YWHAE ZFAND3 ZFAND5
Entrez ID		23373	4214
HPRD ID		06339	19599
Ensembl ID		ENSG00000105662	ENSG00000095015
Uniprot IDs		Q6UUV9	Q13233
PDB IDs			6WHB
Enriched GO Terms of Interacting Partners?
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