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MTUS2 and CDKN1B
Data Source:
BioGRID
(two hybrid)
MTUS2
CDKN1B
Description
microtubule associated scaffold protein 2
cyclin dependent kinase inhibitor 1B
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Centrosome
Cytoplasmic Microtubule
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Microtubule Binding
Protein Homodimerization Activity
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin Binding
Protein-containing Complex Binding
Chaperone Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Death
Negative Regulation Of Cell Growth
Negative Regulation Of Kinase Activity
Negative Regulation Of Phosphorylation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Cellular Response To Lithium Ion
Mitotic Cell Cycle Arrest
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
Prostate cancer
GWAS
Insomnia (caffeine-induced) (
22754043
)
Obesity-related traits (
23251661
)
Triptolide cytotoxicity (
26121980
)
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
31562322
29892016
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Interacting Genes
326 interacting genes:
-
ABHD15
ACSM1
AEN
AFF4
AKT1
ANKRD11
ANKS1A
AQP1
ARL4A
ARNT2
AXIN1
BANF2
BARD1
BCL6
BEX2
BMP7
BYSL
C19orf44
C1orf109
C1orf216
C1orf35
C21orf58
C2CD6
C8orf34
CACNB3
CATIP
CATSPER1
CBX8
CCAR1
CCDC116
CCDC120
CCDC146
CCDC17
CCDC185
CCDC187
CCDC198
CCDC6
CCDC60
CCHCR1
CDC20B
CDC5L
CDC7
CDC73
CDK18
CDK5R1
CDKL3
CDKN1A
CDKN1B
CEP57L1
CEP95
CERK
CHIC2
CNNM3
COG2
CREB5
CRY2
CSF1
CTSZ
CWF19L2
CXCL11
CXCL16
CYSLTR2
DCDC2B
DCTN4
DCX
DDX6
DHRS1
DLGAP4
DLGAP5
DMRT3
DOCK2
DTNB
EHHADH
EIF3D
ENKD1
ENPP7
EXOC8
FAM107A
FAM110A
FAM124B
FAM13C
FAM161A
FAM161B
FAM71E2
FAM74A4
FAM90A1
FASTKD5
FBXL18
FBXO34
FBXW5
FCHSD2
FHL3
FLYWCH1
FNDC11
GADD45GIP1
GAL3ST2
GAS2L2
GEM
GGN
GNL3L
GOLGA2P11
GPKOW
GRAP2
GSTP1
GTF2I
GTPBP10
HAPLN2
HAUS1
HBZ
HCK
HDAC4
HOXB5
HOXB9
HSF2
ICAM4
IL16
INO80B
IQCE
ITGB4
ITGB5
ITSN1
JMY
JOSD1
JRK
KANK2
KAT5
KIF1A
KIFC3
KRT6A
KRT75
KRT76
LENG1
LIMS2
LINC00636
LMO2
LMO3
LMO4
LNX1
LRR1
LYSMD1
MAGEA8
MARK4
MBD3
METTL17
MFAP1
MOS
MRPL11
MTMR6
MYO15B
MYOM1
MYPOP
NDEL1
NDOR1
NEFL
NELFE
NHSL2
NTAQ1
NUBPL
NUDT10
NXF1
ODAD3
ODF1
PCDHB14
PDE4DIP
PDZD4
PIBF1
PIN1
PKN1
PKN3
PKP2
PLEKHN1
PLK4
PLSCR4
POLDIP2
POLDIP3
PPHLN1
PPP1R18
PRKAA1
PRKAA2
PRPF18
PRPF31
PRR35
PSMA1
PSMB1
PTCD1
PTK7
PTPMT1
RAB3IL1
RALY
RANBP3L
RAP1B
RASAL3
RASD1
RBM41
RCOR3
RGS2
RHPN1
RIBC2
RNF6
ROBO3
RPA1
RPL9
RPS19BP1
RTP5
SAMD4A
SCEL
SCNM1
SDCBP
SELENOM
SETD5
SH2D4A
SH3RF2
SHFL
SLC22A5
SLC23A1
SLC25A42
SLC25A48
SLC25A6
SLIRP
SMARCD1
SMARCE1
SMG9
SNAI1
SNHG11
SNRPA
SNRPB2
SNW1
SPATA8
SPATC1L
SPG21
SPG7
STK16
SYT6
TACO1
TAF13
TBC1D22B
TCEA2
TCEANC
TCHP
TEAD4
TEPSIN
THAP7
TLE5
TNIP3
TNNI1
TP53RK
TRIM29
TRIM42
TSGA10IP
TSHZ3
TTC23
TTLL10
TULP2
TXN2
UBTFL1
USP2
USP22
UTP14C
VASN
WAC
ZBTB16
ZBTB38
ZBTB47
ZC2HC1C
ZFC3H1
ZFHX3
ZFP1
ZFP2
ZFP64
ZFYVE21
ZMAT2
ZMYND10
ZNF124
ZNF136
ZNF17
ZNF20
ZNF224
ZNF23
ZNF230
ZNF232
ZNF239
ZNF250
ZNF266
ZNF3
ZNF329
ZNF337
ZNF35
ZNF408
ZNF410
ZNF414
ZNF415
ZNF417
ZNF426
ZNF438
ZNF439
ZNF440
ZNF48
ZNF490
ZNF497
ZNF512B
ZNF557
ZNF564
ZNF572
ZNF580
ZNF581
ZNF587
ZNF599
ZNF607
ZNF613
ZNF624
ZNF648
ZNF655
ZNF669
ZNF670
ZNF696
ZNF76
ZNF764
ZNF774
ZNF775
ZNF785
ZNF792
ZNF837
ZNF844
ZSCAN12
ZSCAN26
73 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE1
CCNE2
CDC34
CDK1
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL1
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RBX1
RCHY1
RNF123
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2I
UBE2L3
UBE3A
UCHL1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
23281
1027
HPRD ID
11108
02867
Ensembl ID
ENSG00000132938
ENSG00000111276
Uniprot IDs
Q5JR59
P46527
Q6I9V6
PDB IDs
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
Enriched GO Terms of Interacting Partners
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