ABRAXAS2 and DCUN1D1

Data Source:
BioGRID (two hybrid)

		ABRAXAS2	DCUN1D1
Description		abraxas 2, BRISC complex subunit	defective in cullin neddylation 1 domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Midbody Spindle Pole Centrosome Microtubule Minus-end BRISC Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Protein Deubiquitination Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly	Regulation Of Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		Metalloprotease DUBs	Neddylation
Drugs
Diseases
GWAS		Bone mineral content ( 31790847)	Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		7 interacting genes: DCUN1D1 NUMA1 SHMT2 SMURF2 THAP5 UBC USP7	33 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		23172	54165
HPRD ID		13783	12067
Ensembl ID		ENSG00000165660	ENSG00000043093
Uniprot IDs		Q15018	B4DM76 C9JVE2 Q96GG9
PDB IDs		6H3C 6R8F	3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W
Enriched GO Terms of Interacting Partners?
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