ARHGEF15 and C11orf49

Data Source:
HPRD (two hybrid)

		ARHGEF15	C11orf49
Description		Rho guanine nucleotide exchange factor 15	chromosome 11 open reading frame 49
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Activation Of GTPase Activity Negative Regulation Of Synapse Maturation
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) Platelet distribution width ( 32888494) Total cholesterol levels ( 30275531)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) D-dimer levels ( 21502573) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29617998) Neurociticism ( 29500382)
Interacting Genes		14 interacting genes: C11orf49 CDC42 CEP55 DNAJC5 EPHA4 ESR1 ESRRG GORASP2 LASP1 MOB4 PIN1 PRKG1 RHOA SH3RF1	19 interacting genes: ARHGEF15 CDC16 ENY2 FH GCA GSR PHF1 PNMA5 PRKAR1A PSMA1 RAB17 RAB29 RBM48 RPL8 RPS3A TXN2 UBE3A UBQLN4 ZFHX3
Entrez ID		22899	79096
HPRD ID		10535	08332
Ensembl ID		ENSG00000198844	ENSG00000149179
Uniprot IDs		A0A0S2Z547 O94989	B4DUV7 Q9H6J7
PDB IDs
Enriched GO Terms of Interacting Partners?
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