FGF10 and FBXO7

Data Source:
BioGRID (enzymatic study)

		FGF10	FBXO7
Description		fibroblast growth factor 10	F-box protein 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface Collagen-containing Extracellular Matrix	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Neurite Lewy Body Core Lewy Body Corona
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Heterodimerization Activity Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation MAPK Cascade Activation Of MAPK Activity Angiogenesis Metanephros Development Organ Induction Mesonephros Development Positive Regulation Of Protein Phosphorylation Blood Vessel Remodeling Metanephros Morphogenesis Determination Of Left/right Symmetry Salivary Gland Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Keratinocyte Proliferation Pituitary Gland Development Cell Differentiation Regulation Of Cell Migration Embryonic Genitalia Morphogenesis Thyroid Gland Development Otic Vesicle Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Hair Follicle Morphogenesis Embryonic Camera-type Eye Development Actin Cytoskeleton Reorganization Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of ATPase Activity Lacrimal Gland Development Regulation Of Activin Receptor Signaling Pathway Protein Localization To Cell Surface Somatic Stem Cell Population Maintenance Wound Healing Tissue Regeneration Odontogenesis Of Dentin-containing Tooth Muscle Cell Fate Commitment Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Embryonic Digestive Tract Morphogenesis Branching Morphogenesis Of An Epithelial Tube Female Genitalia Morphogenesis Male Genitalia Morphogenesis Positive Regulation Of Lymphocyte Proliferation Epithelial Cell Proliferation Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation White Fat Cell Differentiation Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Radial Glial Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Limb Development Limb Bud Formation Lung Epithelium Development Lung Saccule Development Bronchiole Morphogenesis Bud Outgrowth Involved In Lung Branching Bud Elongation Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Lung Development Type II Pneumocyte Differentiation Prostatic Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Submandibular Salivary Gland Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Branch Elongation Involved In Salivary Gland Morphogenesis Semicircular Canal Fusion Mesenchymal Cell Differentiation Involved In Lung Development Secretion By Lung Epithelial Cell Involved In Lung Growth Lung Proximal/distal Axis Specification Tear Secretion Positive Regulation Of White Fat Cell Proliferation ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Harderian Gland Development Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Polyubiquitination Autophagy Of Mitochondrion Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Regulation Of Neuron Projection Development Protein Ubiquitination Regulation Of Protein Stability Regulation Of Locomotion Post-translational Protein Modification Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR1b ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Regulation of gene expression in early pancreatic precursor cells Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Aplasia of lacrimal and salivary glands Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome	Parkinson's disease (PD)
GWAS		Alzheimer disease and age of onset ( 26830138) Basal cell carcinoma ( 31174203) Breast cancer ( 29059683 31757997) Dentures ( 31235808) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) High altitude adaptation ( 28373541) Keratinocyte cancer (MTAG) ( 31174203) Lung function (FVC) ( 30804560) Nonsyndromic cleft lip with cleft palate ( 28232668) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease ( 26227905) Prostate cancer ( 21743467) Refractive error ( 32231278)	Blood protein levels ( 29875488) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: FBXO7 FGFR1 FGFR2 POMC SREK1IP1 THAP1	345 interacting genes: AATF ABCF3 ABL1 ACOT8 ACSL5 ACSM3 ACTC1 ACVR1 ACVR2B AK8 AKAP14 AKIRIN2 AKT3 ALKBH3 AMOTL2 ANGPTL7 ANKRD36BP1 ANP32E APEX1 APOBEC3C APOBEC4 ASPH ASPHD1 ATAT1 ATF5 ATP5F1C BAG3 BCKDK BIRC2 BLK BUB1 BUB1B C11orf16 C15orf48 C1orf105 C1orf115 C22orf31 C2orf88 CACYBP CAMK1 CAPN5 CASQ2 CCBE1 CCDC186 CCDC60 CCDC88C CCNE2 CDC34 CDK10 CDK14 CENPJ CEP112 CFAP300 CHCHD2 CHCHD6 CHMP2B CHMP3 CILK1 CIRBP CKAP2 CLHC1 CLIP3 CMTR2 CNOT7 COLEC12 CPEB4 CSNK1E CXCL12 CXCL9 DDRGK1 DDX10 DHRS2 DHX40 DNAH14 DNAJA3 DNAJB12 DNAJC30 DPY19L2P1 DRAP1 ELF4 EP400P1 EPHA3 EPHB2 EPHB3 EPHB4 ERBB2 ERICH2 FGF10 FGF13 FGFR1 FGFR2 FMOD FUT8 FYTTD1 GADD45GIP1 GAPDH GBP2 GEMIN2 GGA2 GLCE GLIPR2 GLRX2 GMCL2 GNLY GORAB GPAM GPKOW GRK6 GSK3B H1-0 H2AZ2 H3-3B HADH HMG20A HMG20B HMGB2 HMGCS2 HNRNPK HPF1 IDH2 IFT88 IGKV1-5 IL4 IL7 ILKAP INKA2 INPP5K INTS7 IPO9 IRF3 JADE2 KCNAB1 KCTD14 KHDRBS3 KIAA1586 KIF12 KIFC3 KIRREL3-AS3 KLF4 KMO KPNA5 LETMD1 LGALS3BP LIMK1 LIMK2 LINC01483 LMNA LRRC20 LRRC8E LRRFIP1 MAK MAP2K6 MAPK10 MAPK9 MAPRE2 MARK2 MARK3 MBD5 MBNL1 MCM2 MCM5 MDK MED22 MED27 MEF2D MEST MIR1-1HG-AS1 MIS18BP1 MITF MMP13 MMP8 MNDA MOB3A MOB3C MPG MPP3 MPZL1 MRM3 MRPL27 MRPS14 MTIF3 MTUS1 MYOG NANS NDE1 NFIA NFIC NKD2 NPHP1 NUDT16L1 NUMB NVL ODF2L OLFML2A OR14K1 ORC3 OSTF1 PABPC3 PACRG PAFAH1B1 PAK6 PCBD2 PDCD7 PDE12 PDE4D PDGFB PGAP4 PHLDA1 PIEZO1 PIGY PIM1 PIM2 PINK1 PLEKHA1 PNOC PNRC2 POLDIP2 POLR2K PPHLN1 PPP1CB PPP1R17 PPP1R21 PRAME PRICKLE2 PRKACB PRKCA PRKCB PRKCG PRKN PRMT1 PRRC2B PUF60 PUSL1 QKI RBBP6 RBM23 RBM33 RCC1 REEP3 REEP4 RET RGS1 RGS22 RNF121 RNF20 RORB RPL14 RPL26 RPL36A RPL37A RPL3L RPL6 RPS15A RPS18 RPS19BP1 RPS2 RPS6KA3 RPS6KB1 RSL24D1 RWDD4 S100A13 S100A16 S100B SAMHD1 SCARA5 SDCCAG8 SEC16B SEC24C SET SFR1 SHMT1 SHMT2 SKP1 SLAIN1 SLC25A26 SLC35B3 SLC7A6OS SMARCD1 SMOC2 SNAP25 SNRPA SNX33 SPATA4 SPDYA SPRY2 SRCIN1 SRPK3 SRSF10 SRSF7 SS18L2 STAT6 STYX TAF9B TARDBP TBC1D3P2 TBPL1 TC2N TCP10L3 TEAD4 TEC TECR TECRL TENT5D TEX29 TGIF2 THAP7 TLE3 TMED10 TMEM120A TMEM237 TMOD2 TMPRSS5 TOMM20 TRAPPC12 TRIB3 TRIM44 TSBP1 TSLP UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2M UROD USF1 USH1C UXS1 UXT VPS16 VRK3 WDR18 WDR24 XPO1 XRN1 YPEL5 ZBTB44 ZC2HC1C ZFYVE21 ZKSCAN8 ZMYM5 ZNF462 ZNF574 ZNF684 ZNF688
Entrez ID		2255	25793
HPRD ID		03665	07292
Ensembl ID		ENSG00000070193	ENSG00000100225
Uniprot IDs		O15520	Q9Y3I1
PDB IDs		1NUN	4L9C 4L9H
Enriched GO Terms of Interacting Partners?
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