ETFA and CYP11A1

Data Source:
BioGRID (affinity chromatography technology)

		ETFA	CYP11A1
Description		electron transfer flavoprotein subunit alpha	cytochrome P450 family 11 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Heme Binding
	Biological Process	Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus
Pathways		Respiratory electron transport	Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs			Aminoglutethimide
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Diverticular disease ( 30177863) Glioma ( 28346443) Heel bone mineral density ( 30598549) Non-glioblastoma glioma ( 28346443 26424050) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		5 interacting genes: CDC42 ETFB FBXL17 HSPB2 PSEN1	5 interacting genes: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9
Entrez ID		2108	1583
HPRD ID		01979	00326
Ensembl ID		ENSG00000140374	ENSG00000140459
Uniprot IDs		A0A0S2Z3L0 P13804	A0A0S2Z3R3 P05108
PDB IDs		1EFV 1T9G 2A1T 2A1U	3N9Y 3N9Z 3NA0 3NA1
Enriched GO Terms of Interacting Partners?
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