LVRN and TICAM2

Data Source:
BioGRID (affinity chromatography technology)

		LVRN	TICAM2
Description		laeverin	toll like receptor adaptor molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Phagocytic Cup Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Endosome Membrane COPII-coated ER To Golgi Transport Vesicle Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection
	Molecular Function	Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity	Protein Binding
	Biological Process	Proteolysis Signal Transduction Regulation Of Blood Pressure Peptide Catabolic Process	MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phagocytosis Inflammatory Response Golgi Organization I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Innate Immune Response Necroptotic Process Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways			Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Spontaneous preterm birth without premature rupture of membranes ( 31194736)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		2 interacting genes: IFIT3 LMNA	19 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6
Entrez ID		206338	353376
HPRD ID		07118	16313
Ensembl ID		ENSG00000172901	ENSG00000243414
Uniprot IDs		Q0P5U8 Q6Q4G3	Q86XR7
PDB IDs			2M1W
Enriched GO Terms of Interacting Partners?
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