HTRA4 and ADAM9

Data Source:
BioGRID (genetic interference)

		HTRA4	ADAM9
Description		HtrA serine peptidase 4	ADAM metallopeptidase domain 9
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Space Focal Adhesion Cell Surface Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Insulin-like Growth Factor Binding Identical Protein Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding
	Biological Process	Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Activation Of MAPKK Activity Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Keratinocyte Differentiation Positive Regulation Of Cell Migration Membrane Protein Intracellular Domain Proteolysis Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways			Collagen degradation
Drugs			INCB7839
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS			Basophil count ( 32888494)
Interacting Genes		1 interacting genes: GTF2IRD1	9 interacting genes: ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		203100	8754
HPRD ID		08818	04091
Ensembl ID		ENSG00000169495	ENSG00000168615
Uniprot IDs		P83105	Q13443
PDB IDs			1M1V
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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