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AGT and PRCP
Data Source:
HPRD
(in vitro)
AGT
PRCP
Description
angiotensinogen
prolylcarboxypeptidase
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Plasma Membrane
Azurophil Granule Membrane
Intracellular Membrane-bounded Organelle
Basal Part Of Cell
Extracellular Exosome
Ficolin-1-rich Granule Membrane
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Hormone Activity
Protein Binding
Growth Factor Activity
Type 1 Angiotensin Receptor Binding
Type 2 Angiotensin Receptor Binding
Serine-type Carboxypeptidase Activity
Protein Binding
Dipeptidyl-peptidase Activity
Biological Process
Activation Of MAPK Activity
Regulation Of Cell Growth
Positive Regulation Of Cytokine Production
Kidney Development
Blood Vessel Remodeling
Regulation Of Blood Volume By Renin-angiotensin
Renin-angiotensin Regulation Of Aldosterone Production
Regulation Of Renal Output By Angiotensin
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Renal System Process
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Nitric Oxide Mediated Signal Transduction
Cell-cell Signaling
Regulation Of Blood Pressure
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Negative Regulation Of Endopeptidase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Muscle Activity Involved In Regulation Of Muscle Adaptation
Regulation Of Lipid Metabolic Process
Regulation Of Vasoconstriction
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Regulation Of Cell Population Proliferation
Vasoconstriction
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Gap Junction Assembly
Regulation Of Cardiac Conduction
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Thyroid Hormone Mediated Signaling Pathway
Plasma Kallikrein-kinin Cascade
Negative Regulation Of Systemic Arterial Blood Pressure
Proteolysis
Blood Coagulation, Intrinsic Pathway
Glucose Homeostasis
Neutrophil Degranulation
Regulation Of Blood Vessel Endothelial Cell Migration
Angiogenesis Involved In Wound Healing
Energy Homeostasis
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
PPARA activates gene expression
Metabolism of Angiotensinogen to Angiotensins
Metabolism of Angiotensinogen to Angiotensins
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
Intrinsic Pathway of Fibrin Clot Formation
Neutrophil degranulation
Drugs
Zinc
Copper
Sparsentan
Zinc acetate
Diseases
Renal tubular dysgenesis
GWAS
Blood protein levels (
30072576
)
Coronary artery disease (
29212778
33020668
)
Diastolic blood pressure (
27841878
28739976
27618452
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Diastolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Mean arterial pressure (
27618448
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Pancreatic ductal adenocarcinoma (
30541042
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Systolic blood pressure (
27841878
27618452
30578418
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Blood protein levels (
30072576
29875488
)
Colorectal or endometrial cancer (
26621817
)
Metabolite levels (
23823483
)
Urate levels (BMI interaction) (
25811787
)
Interacting Genes
23 interacting genes:
ACE2
AGTR1
AGTR2
ATP6AP2
CMA1
CTSG
DNPEP
ECE1
ENPEP
EWSR1
GRB2
GSDMB
ITSN2
KNG1
LNPEP
MAS1
MEP1A
MME
PRCP
PREP
PRG2
REN
TP53
2 interacting genes:
AGT
VDR
Entrez ID
183
5547
HPRD ID
00106
08352
Ensembl ID
ENSG00000135744
ENSG00000137509
Uniprot IDs
B0ZBE2
B2R5S1
P01019
A0A024R5L0
B7Z7Q6
P42785
PDB IDs
1N9U
1N9V
2JP8
2WXW
2X0B
3CK0
3WOO
3WOR
4AA1
4APH
4FYS
5E2Q
5M3X
5M3Y
5XJM
6I3F
6I3I
6JOD
6OS0
7C6A
3N2Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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