DRD4 and CARS1

Data Source:
HPRD (in vivo, in vitro)

		DRD4	CARS1
Description		dopamine receptor D4	cysteinyl-tRNA synthetase 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding	TRNA Binding Cysteine-tRNA Ligase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity	TRNA Aminoacylation For Protein Translation Cysteinyl-tRNA Aminoacylation
Pathways		Dopamine receptors G alpha (i) signalling events	Cytosolic tRNA aminoacylation
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil	Cysteine
Diseases
GWAS
Interacting Genes		9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1	5 interacting genes: APP EEF1G SUMO2 TRIM55 TRIM63
Entrez ID		1815	833
HPRD ID		00541	00464
Ensembl ID		ENSG00000069696	ENSG00000110619
Uniprot IDs		P21917	A0A024RCG3 B4DPV7 P49589
PDB IDs		5WIU 5WIV
Enriched GO Terms of Interacting Partners?
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