ASXL1 and SRM

Data Source:
BioGRID (two hybrid)

		ASXL1	SRM
Description		ASXL transcriptional regulator 1	spermidine synthase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm PR-DUB Complex	Cytosol
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Spermidine Synthase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Morphogenesis Heart Morphogenesis Transcription, DNA-templated Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Protein Deubiquitination Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development	Polyamine Metabolic Process Polyamine Biosynthetic Process Spermidine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		UCH proteinases	Metabolism of polyamines
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Beard thickness ( 26926045)
Interacting Genes		6 interacting genes: APP GOLGA6L9 H1-2 SRPK1 STAT3 UBC	3 interacting genes: CDC42 SOX12 TERF1
Entrez ID		171023	6723
HPRD ID		16516	01692
Ensembl ID		ENSG00000171456	ENSG00000116649
Uniprot IDs		Q498B9 Q8IXJ9	P19623
PDB IDs			2O05 2O06 2O07 2O0L 3RW9
Enriched GO Terms of Interacting Partners?
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