KCNG3 and CEP250

Data Source:
BioGRID (affinity chromatography technology)

		KCNG3	CEP250
Description		potassium voltage-gated channel modifier subfamily G member 3	centrosomal protein 250
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways		Voltage gated Potassium channels	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS		Body mass index ( 25673413) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thrombosis ( 26908601)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 25429064 18391951) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: KCNB1 KCNB2 KCNC1 KCNF1	6 interacting genes: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG
Entrez ID		170850	11190
HPRD ID		16232	09877
Ensembl ID		ENSG00000171126	ENSG00000126001
Uniprot IDs		Q8TAE7	Q9BV73
PDB IDs			6OQA
Enriched GO Terms of Interacting Partners?
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