DDX10 and IGFBP6

Data Source:
BioGRID (proximity labelling technology)

		DDX10	IGFBP6
Description		DEAD-box helicase 10	insulin like growth factor binding protein 6
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GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	RRNA Processing Anterior Head Development	Activation Of MAPK Activity Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		3 interacting genes: APP FBXO7 SIRPA	37 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 EFEMP1 EFEMP2 ENKD1 EPDR1 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		1662	3489
HPRD ID		03138	00902
Ensembl ID		ENSG00000178105	ENSG00000167779
Uniprot IDs		Q13206	P24592
PDB IDs		2PL3	1RMJ
Enriched GO Terms of Interacting Partners?
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