AARS1 and DHX38

Data Source:
BioGRID (two hybrid)

		AARS1	DHX38
Description		alanyl-tRNA synthetase 1	DEAH-box helicase 38
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome
	Molecular Function	TRNA Binding Aminoacyl-tRNA Editing Activity Ser-tRNA(Ala) Hydrolase Activity Alanine-tRNA Ligase Activity ATP Binding Zinc Ion Binding Amino Acid Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding
	Biological Process	TRNA Modification TRNA Aminoacylation For Protein Translation Alanyl-tRNA Aminoacylation TRNA Processing Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing
Pathways		Cytosolic tRNA aminoacylation	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Alanine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 28240269 23696881) Cholesterol, total ( 25961943 20686565) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: CDC42 EEF1B2 LINC01554 SUMO2	8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C SNRNP200 TERF2IP U2AF1 WBP4
Entrez ID		16	9785
HPRD ID		03042	05720
Ensembl ID		ENSG00000090861	ENSG00000140829
Uniprot IDs		P49588	Q92620
PDB IDs		4XEM 4XEO 5KNN 5T5S 5T76 5V59	5YZG 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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