SGO1 and POLE4

Data Source:
BioGRID (biochemical)

		SGO1	POLE4
Description		shugoshin 1	DNA polymerase epsilon 4, accessory subunit
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleoplasm Centrosome Cytosol	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex
	Molecular Function	Protein Binding Kinase Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Homologous Chromosome Segregation Meiotic Sister Chromatid Cohesion Cell Division Mitotic Sister Chromatid Cohesion, Centromeric	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS
Interacting Genes		20 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6	7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A
Entrez ID		151648	56655
HPRD ID		12377	16238
Ensembl ID		ENSG00000129810	ENSG00000115350
Uniprot IDs		A0A024R2J4 B5BUA4 Q5FBB7	Q9NR33
PDB IDs		3FGA 3Q6S 4A0I
Enriched GO Terms of Interacting Partners?
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