ZBTB46 and DESI1

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		ZBTB46	DESI1
Description		zinc finger and BTB domain containing 46	desumoylating isopeptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding	Protein Binding Identical Protein Binding Importin-alpha Family Protein Binding SUMO-specific Isopeptidase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Differentiation	Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Removal
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Birth weight ( 31043758) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421) Marginal zone lymphoma or multiple sclerosis ( 31407831) Mean corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Processed meat consumption ( 32066663) Prostate cancer ( 23535732) Trunk fat mass adjusted for trunk lean mass ( 32239398) Type 2 diabetes (adjusted for BMI) ( 30297969) Ulcerative colitis ( 28067908 21297633) Urinary albumin-to-creatinine ratio ( 31630189)	General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: DESI1	33 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RNF4 RPS27A SHISA4 SHISA5 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLN2 UBQLNL UHRF2 XPO1 ZBTB46
Entrez ID		140685	27351
HPRD ID		16567	18590
Ensembl ID		ENSG00000130584	ENSG00000100418
Uniprot IDs		A0A494BZW5 Q6ZMU8 Q86UZ6	Q6ICB0
PDB IDs			3EBQ
Enriched GO Terms of Interacting Partners?
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