COL6A1 and LCMT2

Data Source:
BioGRID (genetic interference)

		COL6A1	LCMT2
Description		collagen type VI alpha 1 chain	leucine carboxyl methyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Membrane Protein-containing Complex Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome	Cytoplasm
	Molecular Function	Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding	Protein Binding TRNA Methyltransferase Activity
	Biological Process	Osteoblast Differentiation Cell Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Cellular Response To Amino Acid Stimulus	TRNA Modification TRNA Methylation Wybutosine Biosynthetic Process
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Synthesis of wybutosine at G37 of tRNA(Phe) Synthesis of wybutosine at G37 of tRNA(Phe)
Drugs			Leucine
Diseases		Ossification of the posterior longitudinal ligament of spine (OPLL) Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Blood protein levels ( 30072576 29875488) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Corneal hysteresis ( 30894546) Corneal resistance factor ( 31246245 30894546) Diverticular disease ( 30177863) Intraocular pressure ( 29617998 29235454) Myopia ( 27182965) Pulse pressure ( 30224653 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 28234671) Waist circumference adjusted for body mass index ( 25673412)	Hemoglobin levels ( 32327693)
Interacting Genes		10 interacting genes: COL2A1 DCN DNAJB11 FGF7 LAMB1 LGALS3BP MAG MTDH PDGFA PDGFB	1 interacting genes: ACTN4
Entrez ID		1291	9836
HPRD ID		00370	17267
Ensembl ID		ENSG00000142156	ENSG00000168806
Uniprot IDs		A0A384P5H7 P12109	O60294
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?