WFDC12 and ADA

Data Source:
HPRD (in vivo)

		WFDC12	ADA
Description		WAP four-disulfide core domain 12	adenosine deaminase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Space Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Vesicle Lumen
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response	Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Cell Adhesion Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Drug Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion
Pathways			Purine salvage
Drugs			Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases			T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Bipolar disorder ( 31043756)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233)
Interacting Genes		6 interacting genes: ASPH SGTA SGTB SLC39A7 UBQLN1 UBQLN2	11 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2
Entrez ID		128488	100
HPRD ID		15674	00038
Ensembl ID		ENSG00000168703	ENSG00000196839
Uniprot IDs		Q8WWY7	A0A0S2Z381 F5GWI4 P00813
PDB IDs			1M7M 3IAR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?