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CCR7 and CCL19
Data Source:
HPRD
(in vitro, in vivo)
CCR7
CCL19
Description
C-C motif chemokine receptor 7
C-C motif chemokine ligand 19
Image
GO Annotations
Cellular Component
Mitochondrion
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Extracellular Region
Extracellular Space
Molecular Function
G Protein-coupled Receptor Activity
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Chemokine (C-C Motif) Ligand 19 Binding
Chemokine (C-C Motif) Ligand 21 Binding
C-C Motif Chemokine 19 Receptor Activity
C-C Motif Chemokine 21 Receptor Activity
Protein Binding
Chemokine Activity
CCR7 Chemokine Receptor Binding
CCR10 Chemokine Receptor Binding
Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Biological Process
Establishment Of T Cell Polarity
Positive Regulation Of Cell-matrix Adhesion
Dendritic Cell Chemotaxis
Myeloid Dendritic Cell Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Positive Regulation Of Hypersensitivity
Positive Regulation Of Humoral Immune Response
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Calcium-mediated Signaling
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Pseudopodium Assembly
Ruffle Organization
Response To Lipopolysaccharide
Regulation Of Interferon-gamma Production
Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-12 Production
Response To Prostaglandin E
Chemokine (C-C Motif) Ligand 19 Signaling Pathway
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Thymic T Cell Selection
Positive Regulation Of Cell Adhesion
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Homeostasis Of Number Of Cells
Positive Regulation Of T Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Cytokine Stimulus
Response To Nitric Oxide
Positive Regulation Of Neutrophil Chemotaxis
Activation Of GTPase Activity
Lymphocyte Migration Into Lymph Node
Mature Conventional Dendritic Cell Differentiation
Positive Regulation Of Cell Motility
Positive Regulation Of Dendritic Cell Chemotaxis
Positive Regulation Of Immunological Synapse Formation
Positive Regulation Of T Cell Costimulation
Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation
Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Establishment Of T Cell Polarity
Immunological Synapse Formation
Dendritic Cell Chemotaxis
Myeloid Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Cellular Calcium Ion Homeostasis
Inflammatory Response
Immune Response
Cell Communication
G Protein-coupled Receptor Signaling Pathway
Activation Of JUN Kinase Activity
Response To Virus
Positive Regulation Of Glycoprotein Biosynthetic Process
Cytokine-mediated Signaling Pathway
Neutrophil Chemotaxis
T Cell Costimulation
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Prostaglandin E
Positive Regulation Of T Cell Proliferation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of GTPase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Endocytosis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Lymphocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Cell Maturation
Positive Regulation Of Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Cell Projection Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Response To Nitric Oxide
Positive Regulation Of Neutrophil Chemotaxis
Mature Conventional Dendritic Cell Differentiation
Cellular Response To Virus
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cell Motility
Positive Regulation Of Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Asthma (
31959851
30929738
)
Asthma (childhood onset) (
30929738
)
Eczema (
31361310
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Type 1 diabetes (
25751624
)
Metabolite levels (
23823483
)
Rheumatoid arthritis (
30423114
24390342
)
Interacting Genes
3 interacting genes:
CCL19
CCL21
CCR10
8 interacting genes:
ACKR2
ACKR4
CCL22
CCR10
CCR7
CXCL13
MEOX2
PF4V1
Entrez ID
1236
6363
HPRD ID
02588
03750
Ensembl ID
ENSG00000126353
ENSG00000172724
Uniprot IDs
A0N0Q0
J3KSS9
P32248
Q6IBD6
Q99731
PDB IDs
6QZH
2MP1
Enriched GO Terms of Interacting Partners
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