CNTRL and ENG

Data Source:
BioGRID (affinity chromatography technology)

		CNTRL	ENG
Description		centriolin	endoglin
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Microtubule Organizing Center Cytosol Membrane Perinuclear Region Of Cytoplasm Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Protein Binding Cytoskeletal Protein Binding	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Kidney Development Ventricular Septum Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Aorta Development Cell Division Regulation Of Cytoskeleton Organization Coronary Vasculature Development Ciliary Basal Body-plasma Membrane Docking	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Heart Looping Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Dorsal Aorta Morphogenesis Response To Drug Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Protein Kinase B Signaling Atrial Cardiac Muscle Tissue Morphogenesis Bone Development Extracellular Matrix Constituent Secretion Cellular Response To Mechanical Stimulus Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Carotuximab
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Pulse pressure ( 27841878)	Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148)
Interacting Genes		3 interacting genes: MAP3K4 MAPK6 TRADD	13 interacting genes: ACVR1 ACVR2A BMP2 BMP7 DYNLT4 GDF2 INHBA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3
Entrez ID		11064	2022
HPRD ID		05691	00565
Ensembl ID		ENSG00000119397	ENSG00000106991
Uniprot IDs		B2RP65 Q7Z7A1	A0A024R878 B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs			5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?
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