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PPARGC1A and SIRT1
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro, in vivo)
PPARGC1A
SIRT1
Description
PPARG coactivator 1 alpha
sirtuin 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
PML Body
Cytosolic Ribosome
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Apical Dendrite
Subsarcolemmal Mitochondrion
Interfibrillar Mitochondrion
Chromatin
Euchromatin
Heterochromatin
Fibrillar Center
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Chromatin Silencing Complex
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
PML Body
RDNA Heterochromatin
ESC/E(Z) Complex
Molecular Function
DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
Protein Binding
Transcription Factor Binding
Nuclear Receptor Binding
Estrogen Receptor Binding
Nuclear Receptor Coactivator Activity
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Peroxisome Proliferator Activated Receptor Binding
Alpha-tubulin Binding
Sequence-specific DNA Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
Enzyme Binding
Protein Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Nuclear Hormone Receptor Binding
Histone Binding
Identical Protein Binding
HLH Domain Binding
BHLH Transcription Factor Binding
Metal Ion Binding
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
Mitogen-activated Protein Kinase Binding
NAD+ Binding
Protein-propionyllysine Depropionylase Activity
Keratin Filament Binding
Promoter-specific Chromatin Binding
Biological Process
Response To Reactive Oxygen Species
Autophagy Of Mitochondrion
Temperature Homeostasis
Cellular Glucose Homeostasis
Negative Regulation Of Protein Phosphorylation
Response To Dietary Excess
Response To Ischemia
Galactose Metabolic Process
Gluconeogenesis
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
MRNA Processing
Mitochondrion Organization
Aging
Digestion
Circadian Rhythm
Androgen Metabolic Process
RNA Splicing
Response To Cold
Positive Regulation Of Gene Expression
Positive Regulation Of Mitochondrion Organization
Skeletal Muscle Atrophy
Response To Muscle Activity
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Negative Regulation Of Smooth Muscle Cell Migration
Fatty Acid Oxidation
Cerebellum Development
Respiratory Electron Transport Chain
Forebrain Development
Circadian Regulation Of Gene Expression
Cellular Response To Oxidative Stress
Positive Regulation Of Histone Acetylation
Cellular Response To Potassium Ion
Response To Drug
Response To Starvation
Regulation Of Circadian Rhythm
Response To Leucine
Negative Regulation Of Neuron Apoptotic Process
Cellular Respiration
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Brown Fat Cell Differentiation
Positive Regulation Of DNA-binding Transcription Factor Activity
Flavone Metabolic Process
Adipose Tissue Development
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Nitrite
Cellular Response To Caffeine
Cellular Response To Fructose Stimulus
Cellular Response To Glucose Stimulus
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To Follicle-stimulating Hormone Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Epinephrine
Response To Norepinephrine
Negative Regulation Of Mitochondrial Fission
Energy Homeostasis
Cellular Response To Thyroid Hormone Stimulus
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Neuron Death
Response To Metformin
Positive Regulation Of Cellular Respiration
Positive Regulation Of Mitochondrial DNA Metabolic Process
Positive Regulation Of Muscle Tissue Development
Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process
Cellular Response To Ionomycin
Cellular Response To Resveratrol
Response To Methionine
Adaptive Thermogenesis
Positive Regulation Of Progesterone Biosynthetic Process
Negative Regulation Of Signaling Receptor Activity
Regulation Of NMDA Receptor Activity
Positive Regulation Of ATP Biosynthetic Process
Single Strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Synthesis Involved In DNA Repair
Angiogenesis
Ovulation From Ovarian Follicle
Cellular Glucose Homeostasis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Adaptive Immune Response
Chromatin Organization
DNA Methylation-dependent Heterochromatin Assembly
Protein ADP-ribosylation
Protein Deacetylation
Triglyceride Mobilization
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Muscle Organ Development
Cell Aging
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Regulation Of Glucose Metabolic Process
Macrophage Cytokine Production
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Histone Deacetylation
Peptidyl-lysine Acetylation
Macrophage Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Prostaglandin Biosynthetic Process
Heterochromatin Assembly
Protein Destabilization
Negative Regulation Of TOR Signaling
Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Insulin
Circadian Regulation Of Gene Expression
Leptin-mediated Signaling Pathway
Regulation Of Smooth Muscle Cell Apoptotic Process
Peptidyl-lysine Deacetylation
Cellular Triglyceride Homeostasis
Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphorylation
Response To Hydrogen Peroxide
Behavioral Response To Starvation
Cholesterol Homeostasis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Leptin
Positive Regulation Of MHC Class II Biosynthetic Process
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Insulin Receptor Signaling Pathway
White Fat Cell Differentiation
Negative Regulation Of Helicase Activity
Positive Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Histone H3-K9 Methylation
Negative Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Androgen Receptor Signaling Pathway
Histone H3-K9 Modification
Cellular Response To Hydrogen Peroxide
Heterochromatin Maintenance
Regulation Of Bile Acid Biosynthetic Process
UV-damage Excision Repair
Histone H3 Deacetylation
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Histone H3-K14 Acetylation
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Protein Depropionylation
Regulation Of Cellular Response To Heat
Negative Regulation Of Histone H3-K9 Trimethylation
Negative Regulation Of Neuron Death
Negative Regulation Of Protein Acetylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Adipose Tissue Development
Histone H3-K9 Deacetylation
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Histone H4-K16 Acetylation
Negative Regulation Of Cellular Response To Testosterone Stimulus
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
Pathways
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Circadian Clock
Circadian Clock
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Regulation of HSF1-mediated heat shock response
Circadian Clock
SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Drugs
Resveratrol
Selisistat
Cambinol
Diseases
GWAS
Coffee consumption (
31046077
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Corneal astigmatism (
29422769
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Essential tremor (
27797806
)
Estimated glomerular filtration rate (
31152163
31015462
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Lead levels (
26025379
)
Molar-incisor hypomineralization (
23918034
)
PR interval (
32439900
)
Refractive error (
32231278
)
Resting heart rate (
27798624
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
30285260
)
Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) (
31557306
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Atrial fibrillation (
30061737
)
Chronotype (
30696823
)
Diverticular disease (
30177863
)
Molybdenum levels (
26025379
)
Pulse pressure (
30224653
)
Interacting Genes
43 interacting genes:
CAPNS1
CDK6
CREBBP
ESR1
ESR2
ESRRA
ESRRG
FBXW7
GSK3B
HCFC1
HNF4A
LRPPRC
MAPK14
MED1
MED12
MED14
MED17
MYBBP1A
NCL
NCOA1
NCOA6
NDN
NR1H4
NR1I2
NR1I3
NR3C1
NRF1
PPARA
PPARD
PPARG
RARB
RXRA
SIRT1
SKP1
SRSF4
SRSF5
SRSF6
THRB
TP53
UBC
UBE2I
USF1
USF2
63 interacting genes:
AFP
AKT1
AR
ARNTL
BCL11A
BHLHE41
BRIP1
CDK6
CENATAC
CHFR
CLOCK
CSNK2B
CTTN
E2F1
EP300
ESRRA
EZH2
FOS
FOXM1
FOXO1
FOXO3
GAPDH
H1-5
H3C1
HES1
HEY2
HIC1
HIPK2
HNF4A
HOXB9
MAPK8
MAPT
MPHOSPH8
MYCN
NBN
NDN
NMNAT1
NR1H2
NR1H3
NR1H4
PARP1
PML
PPARA
PPARG
PPARGC1A
PRMT1
PSME3
RARA
RELA
RICTOR
RRP8
SATB1
SETD7
SMAD7
SNW1
STK11
STK4
SUMO2
TP53
TP73
TRIM28
UBE2I
VDR
Entrez ID
10891
23411
HPRD ID
05155
08381
Ensembl ID
ENSG00000109819
ENSG00000096717
Uniprot IDs
A0A024R9Q9
Q9UBK2
A0A024QZQ1
A8K128
B0QZ35
E9PC49
Q96EB6
PDB IDs
1XB7
3B1M
3CS8
3D24
3U9Q
3V9T
3V9V
4QJR
4QK4
5Q0I
5TWO
5UNJ
5Z5S
5Z6S
6AD9
6FZF
6FZP
6IZM
6IZN
6K0T
6KXX
6KXY
6LN4
6MS7
6NWK
6NWL
6W9K
6W9L
4I5I
4IF6
4IG9
4KXQ
4ZZH
4ZZI
4ZZJ
5BTR
Enriched GO Terms of Interacting Partners
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