PGRMC1 and GET3

Data Source:
BioGRID (two hybrid)

		PGRMC1	GET3
Description		progesterone receptor membrane component 1	guided entry of tail-anchored proteins factor 3, ATPase
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Steroid Binding Protein Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding
	Biological Process	Heme Biosynthetic Process Neutrophil Degranulation	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Neutrophil degranulation	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Dextromethorphan Nortriptyline Sertraline	ATP
Diseases
GWAS
Interacting Genes		20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 MTNR1A PAM16 PGRMC2 SCAP SGTB TMEM213 ZNF71	41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		10857	439
HPRD ID		02338	03555
Ensembl ID		ENSG00000101856	ENSG00000198356
Uniprot IDs		O00264 Q6IB11	O43681
PDB IDs		4X8Y	6SO5
Enriched GO Terms of Interacting Partners?
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