PDPN and PRDM2

Data Source:
BioGRID (affinity chromatography technology)

		PDPN	PRDM2
Description		podoplanin	PR/SET domain 2
Image
GO Annotations	Cellular Component	Ruffle Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Cell Junction Filopodium Lamellipodium Membrane Cytoplasmic Vesicle Filopodium Membrane Microvillus Membrane Ruffle Membrane Cell Projection Membrane Raft Leading Edge Of Lamellipodium Tetraspanin-enriched Microdomain	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Signaling Receptor Binding Water Transmembrane Transporter Activity Protein Binding Folic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Water Channel Activity Chemokine Binding Chaperone Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Methyltransferase Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Cell Morphogenesis Lymphangiogenesis Amino Acid Transmembrane Transport Water Transport Amino Acid Transport Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Folic Acid Transport Platelet Activation Lung Development Positive Regulation Of Cell Migration Tube Morphogenesis Negative Regulation Of Apoptotic Process Wound Healing, Spreading Of Cells Lymph Node Development Positive Regulation Of Cellular Component Movement Response To Hyperoxia Lymphatic Endothelial Cell Fate Commitment Actin-mediated Cell Contraction Positive Regulation Of Extracellular Matrix Disassembly Cell-cell Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Regulation Of Myofibroblast Contraction Regulation Of Lamellipodium Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Determination Of Adult Lifespan Regulation Of Gene Expression Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		GPVI-mediated activation cascade
Drugs
Diseases
GWAS			Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronotype ( 30696823) Copper levels ( 26025379) Intracranial aneurysm ( 30823506) Left ventricular function change in anthracycline treatment ( 28542097) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Parkinson's disease ( 26227905) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: TMEM14B TOM1L1	6 interacting genes: E2F1 ESR1 H3-4 H3C1 MDM2 RB1
Entrez ID		10630	7799
HPRD ID		16398	03120
Ensembl ID		ENSG00000162493	ENSG00000116731
Uniprot IDs		Q86YL7	Q13029
PDB IDs		3WSR 4YO0 5XCV 7C94	2JV0 2QPW
Enriched GO Terms of Interacting Partners?
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