PITRM1 and MFN2

Data Source:
BioGRID (proximity labelling technology)

		PITRM1	MFN2
Description		pitrilysin metallopeptidase 1	mitofusin 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Outer Membrane Cytosol Integral Component Of Membrane Intrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	Metalloendopeptidase Activity Enzyme Activator Activity Metallopeptidase Activity Zinc Ion Binding	GTPase Activity Protein Binding GTP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Proteolysis Protein Targeting To Mitochondrion Protein Processing Regulation Of Catalytic Activity	Protein Targeting To Mitochondrion Apoptotic Process Response To Unfolded Protein Mitochondrial Membrane Organization Cell Cycle Arrest Blood Coagulation Mitochondrial Fusion Macroautophagy Protein Localization To Phagophore Assembly Site Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Mitochondrial protein import	PINK1-PRKN Mediated Mitophagy Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)	Inflammatory skin disease ( 25574825) Plasma homocysteine levels ( 30339177) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494) Tuberculosis ( 29036319)
Interacting Genes			2 interacting genes: MARCHF5 PRKN
Entrez ID		10531	9927
HPRD ID		07142	08495
Ensembl ID		ENSG00000107959	ENSG00000116688
Uniprot IDs		Q5JRX3	O95140
PDB IDs		4L3T 4NGE 4RPU	6JFK 6JFL 6JFM
Enriched GO Terms of Interacting Partners?
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