BCKDK and SETD1A

Data Source:
BioGRID (affinity chromatography technology)

		BCKDK	SETD1A
Description		branched chain keto acid dehydrogenase kinase	SET domain containing 1A, histone lysine methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex	Chromatin Nucleus Nucleoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity	RNA Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Glucose Metabolic Process Phosphorylation	Brain Development Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization
Pathways		Branched-chain amino acid catabolism	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Parkinson's disease ( 31660654) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Red blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APP EPS8 FBXO7 LSM8 NR5A2 SPTA1 STAT3 TRAF4	5 interacting genes: DPY30 EP300 H3C1 H3C14 LBP
Entrez ID		10295	9739
HPRD ID		12523	13795
Ensembl ID		ENSG00000103507	ENSG00000099381
Uniprot IDs		A0A024QZA9 O14874	O15047
PDB IDs			3S8S 3UVN 4EWR
Enriched GO Terms of Interacting Partners?
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