PTPRU and GNAI3

Data Source:
HPRD (in vivo, in vitro)

		PTPRU	GNAI3
Description		protein tyrosine phosphatase receptor type U	G protein subunit alpha i3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Differentiation Negative Regulation Of Cell Migration Animal Organ Regeneration Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by SCF-KIT	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576) Carotid plaque maximum area ( 32469969) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Mean area of carotid plaque ( 32469969) Mean corpuscular volume ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Schizophrenia ( 28991256) Tourette syndrome ( 30818990)	Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		10 interacting genes: CTNNB1 EGFR ERBB2 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT PPFIA3	43 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		10076	2773
HPRD ID		03908	00765
Ensembl ID		ENSG00000060656	ENSG00000065135
Uniprot IDs		Q92729	P08754
PDB IDs		6SUB 6SUC	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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