HMGXB4 and EPM2A

Data Source:
BioGRID (two hybrid)

		HMGXB4	EPM2A
Description		HMG-box containing 4	EPM2A glucan phosphatase, laforin
Image		No pdb structure
GO Annotations	Cellular Component	NURF Complex	Nucleus
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Positive Regulation Of Macroautophagy Negative Regulation Of TOR Signaling
Pathways			Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Hip circumference adjusted for BMI ( 25673412) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)
Interacting Genes		24 interacting genes: AKAP17A CREBBP EPM2A H3-4 HABP4 INO80B JMJD6 LENG8 MX1 NKAPD1 NR1H2 PIAS2 SRPK2 STAC3 STRBP SUMO2 TENT5B TNNT1 TSC22D1 TSPYL2 UBE2I UBL5 UROD ZCCHC10	16 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 NHLRC1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS
Entrez ID		10042	7957
HPRD ID		05267	06345
Ensembl ID		ENSG00000100281	ENSG00000112425
Uniprot IDs		Q7Z641 Q9UGU5	H0UI04 O95278
PDB IDs			4R30 4RKK
Enriched GO Terms of Interacting Partners?
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