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OFD1

Description OFD1 centriole and centriolar satellite protein
Image No pdb structure
GO Annotations Cellular Component
  • Extracellular Region
  • Nucleus
  • Centrosome
  • Centriole
  • Cytosol
  • Cilium
  • Microtubule Cytoskeleton
  • Membrane
  • Motile Cilium
  • Centriolar Satellite
  • Ciliary Basal Body
Molecular Function
  • Protein Binding
  • Identical Protein Binding
  • Alpha-tubulin Binding
  • Gamma-tubulin Binding
Biological Process
  • G2/M Transition Of Mitotic Cell Cycle
  • Mitotic Cell Cycle
  • Centriole Replication
  • Regulation Of G2/M Transition Of Mitotic Cell Cycle
  • Cilium Assembly
  • Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry
  • Mitotic Spindle Assembly
  • Ciliary Basal Body-plasma Membrane Docking
Pathways
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Hedgehog 'off' state
  • Anchoring of the basal body to the plasma membrane
  • AURKA Activation by TPX2
Drugs
Diseases
  • Oral-facial-digital syndrome 1
  • Joubert syndrome
GWAS
Novel Interacting Genes 2 novel interacting genes: EGFL6 RAI2
Interacting Genes 8 interacting genes: CCSER2 CEP126 EIF6 GPRASP1 LUC7L2 NME7 RUVBL1 S100A6
Entrez ID 8481
HPRD ID 02162
Ensembl ID ENSG00000046651
Uniprot IDs A6NF31 E9KL37 O75665
PDB IDs
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025