SPIRE2

Description		spire type actin nucleation factor 2
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cell Cortex Cytoplasmic Vesicle Membrane Cleavage Furrow
	Molecular Function	Actin Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Actin Cytoskeleton Organization Actin Filament Polymerization Cleavage Furrow Formation Polar Body Extrusion After Meiotic Divisions Actin Nucleation Intracellular Transport Golgi Vesicle Transport Establishment Of Meiotic Spindle Localization Actin Filament Network Formation Formin-nucleated Actin Cable Assembly Positive Regulation Of Double-strand Break Repair
Pathways
Drugs		Latrunculin B
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Low tan response ( 29739929) Mean reticulocyte volume ( 32888494) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Red vs. brown/black hair color ( 30531825) White matter integrity (fractional anisotropy) ( 32358547)
Novel Interacting Genes		1 novel interacting genes: IRF8
Interacting Genes		1 interacting genes: HGS
Entrez ID		84501
HPRD ID		18099
Ensembl ID		ENSG00000204991
Uniprot IDs		Q8WWL2
PDB IDs		5JCY
Enriched GO Terms of Interacting Partners?
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