CACNA1D

Description		calcium voltage-gated channel subunit alpha1 D
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Z Disc Presynapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential
	Biological Process	Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Positive Regulation Of Adenylate Cyclase Activity Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport
Pathways		Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium sulfate Levomenthol Ethanol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Aranidipine Benidipine Cilnidipine Lacidipine Levamlodipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Axial length ( 24144296) Blood protein levels ( 28240269) Body mass index ( 25673413) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010 25249183 30487518 30578418) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) PR interval ( 32439900) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 29403010 25249183 30487518 30578418) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)
Interacting Genes		3 interacting genes: CALB1 FGFR2 STX1A
Entrez ID		776
HPRD ID		00247
Ensembl ID		ENSG00000157388
Uniprot IDs		A0A1B0GUN6 Q01668 Q59GD8
PDB IDs		3LV3
Enriched GO Terms of Interacting Partners?
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