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ROBO1
Description
roundabout guidance receptor 1
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Axon
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
LRR Domain Binding
Identical Protein Binding
Biological Process
Cell Migration Involved In Sprouting Angiogenesis
Outflow Tract Septum Morphogenesis
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Formation
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Nervous System Development
Axon Guidance
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Axon Midline Choice Point Recognition
Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration
Negative Regulation Of Cell Migration
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Rho Protein Signal Transduction
Roundabout Signaling Pathway
Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction
Aorta Development
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Axonogenesis
Negative Regulation Of Negative Chemotaxis
Ventricular Septum Morphogenesis
Negative Regulation Of Chemokine-mediated Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways
Netrin-1 signaling
Signaling by ROBO receptors
Signaling by ROBO receptors
Activation of RAC1
Regulation of commissural axon pathfinding by SLIT and ROBO
Regulation of commissural axon pathfinding by SLIT and ROBO
Inactivation of CDC42 and RAC1
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
SLIT2:ROBO1 increases RHOA activity
Regulation of cortical dendrite branching
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) (
19023125
)
Carotid plaque burden (
28282560
)
Craniofacial microsomia (
26853712
)
Diverticular disease (
30177863
)
Excessive daytime sleepiness (
27992416
)
Facial emotion recognition (
28608620
)
Facial emotion recognition (fearful faces) (
28608620
)
Glomerular filtration rate in chronic kidney disease (
26420894
)
Liver enzyme levels (aspartate transaminase) (
24124411
)
Metabolite levels (
23823483
)
Moderate-to-late spontaneous preterm birth (
31194736
)
Nose size (
27182965
)
Protein quantitative trait loci (
18464913
)
Refractive error (
32231278
)
Schizophrenia (
30285260
)
Staphylococcus aureus nasal carriage (intermittent) (
26569114
)
Takayasu arteritis (
25604533
)
Visceral adipose tissue (
26480920
)
Novel Interacting Genes
1 novel interacting genes:
MYCBP
Interacting Genes
9 interacting genes:
ABL1
MAGEB6
MAPK14
ROBO2
SLIT1
SLIT2
SRGAP1
SRGAP2
TUBB3
Entrez ID
6091
HPRD ID
03890
Ensembl ID
ENSG00000169855
Uniprot IDs
Q1RMC8
Q9Y6N7
PDB IDs
2EO9
2V9Q
2V9R
2V9T
3WIH
4HLJ
5O5G
5O5I
5OPE
6A77
6A78
6A79
Enriched GO Terms of Interacting Partners
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