LRRC8D

Description		leucine rich repeat containing 8 VRAC subunit D
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Membrane Ion Channel Complex
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Inorganic Anion Transport Taurine Transport Aspartate Transmembrane Transport Transmembrane Transport Cellular Response To Osmotic Stress Anion Transmembrane Transport
Pathways		Miscellaneous transport and binding events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Cognitive function ( 25644384) Lung cancer ( 28604730) Mean platelet volume ( 32888494) Obsessive-compulsive symptoms ( 26859814) Squamous cell lung carcinoma ( 28604730) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)
Novel Interacting Genes		1 novel interacting genes: LRRC8B
Interacting Genes		2 interacting genes: APP EXOSC4
Entrez ID		55144
HPRD ID		11287
Ensembl ID		ENSG00000171492
Uniprot IDs		B3KRU1 Q7L1W4 Q96GG5
PDB IDs		6M04
Enriched GO Terms of Interacting Partners?
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