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ATR
Description
ATR serine/threonine kinase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Chromosome
Golgi Apparatus
PML Body
Molecular Function
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
MutLalpha Complex Binding
MutSalpha Complex Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
DNA Damage Checkpoint
Telomere Maintenance
DNA Replication
DNA Repair
Cellular Response To DNA Damage Stimulus
Multicellular Organism Development
Negative Regulation Of DNA Replication
Peptidyl-serine Phosphorylation
Replication Fork Processing
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To UV
Interstrand Cross-link Repair
Response To Drug
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Autophosphorylation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Gamma Radiation
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Pathways
Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Drugs
Diseases
Alveolar rhabdomyosarcoma
Seckel syndrome
GWAS
Eosinophil counts (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
29403010
32888494
27863252
)
Red cell distribution width (
32888494
28957414
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
50 interacting genes:
AATF
ABL1
AP1B1
AP3B1
ARHGEF1
ATM
BLM
BRCA1
BRCA2
CDKN2C
CEP164
CHD4
CHEK1
CHEK2
CHUK
CLSPN
CREB1
DCAF1
DCLRE1C
DTL
E2F1
E4F1
EEF1E1
EP300
ETV1
FANCA
FANCD2
FANCI
FLT1
H2AX
KDR
LIG4
MCM2
MCPH1
MRE11
MSH2
NBN
PA2G4
PIK3CA
POLD1
POLN
PPP2R3A
RAD17
RASSF1
RHEB
TP53
TREX1
UPF1
XPA
XRCC5
Entrez ID
545
HPRD ID
08369
Ensembl ID
ENSG00000175054
Uniprot IDs
Q13535
PDB IDs
5YZ0
Enriched GO Terms of Interacting Partners
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