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POU1F1

Description POU class 1 homeobox 1
Image
GO Annotations Cellular Component
  • Chromatin
  • Nucleus
  • Nucleoplasm
  • Cytosol
Molecular Function
  • RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
  • DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
  • RNA Polymerase II Transcription Factor Binding
  • RNA Polymerase II Activating Transcription Factor Binding
  • DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
  • DNA-binding Transcription Factor Activity
  • Protein Binding
  • Sequence-specific Double-stranded DNA Binding
Biological Process
  • Negative Regulation Of Transcription By RNA Polymerase II
  • Regulation Of Transcription, DNA-templated
  • Regulation Of Transcription By RNA Polymerase II
  • Negative Regulation Of Cell Population Proliferation
  • Adenohypophysis Development
  • Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
  • Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
  • Menarche (age at onset) ( 25231870)
  • Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes 22 interacting genes: ARID5A ARSA CREBBP ETS1 GATA2 JUN KRTAP10-8 KRTAP15-1 KRTAP6-1 LASP1 LHX4 MSX2 NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG RAD54L2 UBE2I VDR
Entrez ID 5449
HPRD ID 01409
Ensembl ID ENSG00000064835
Uniprot IDs P28069
PDB IDs 5WC9
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025